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Wellington Laboratories continues to support and participate in scientific research and development. Not only does this research increase the knowledge of our staff, it allows them to work with other experts in the field and help us improve our products and technical support.
As can be seen, the synthetic expertise of Wellington Laboratories is supported by strong analytical capabilities. Our published research represents a minor portion of the day-to-day research carried out at Wellington Laboratories. Such research was the impetus for the formation of Wellington Laboratories and will continue to be the foundation of our company and the strength of our people. The company's commitment is to continue its support and participation in scientific research.
The staff at WELLINGTON have well over 200 publications and examples of some of these are given below.
2012
Mundy, L.J., Crump, D., Jones, S.P., Konstantinov, A., Utley, F., Potter, D., Kennedy, S.W., 2012. Induction of cytochrome P4501A by highly purified hexachlorobenzene in primary cultures of ring-necked pheasant and Japanese quail embryo hepatocytes. Comparative Biochemistry and Physiology, Part C 155, 498-505.
2011
Shen, L., Reiner, E.J., Macpherson, K.A., Kolic, T.M., Helm, P.A., Richman, L.A., Marvin, C.H., Burniston, D.A., Hill, B., Brindle, I.D., McCrindle, R., Chittim, B.G., 2011. Dechloranes 602, 603, 604, Dechlorane Plus, and Chlordene Plus, a Newly Detected Analogue, in Tributary Sediments of the Laurentian Great Lakes. Environmental Science & Technology 45, 693-699.
Riddell, N., Becker, R., Chittim, B., Emmerling, F., Koeppen, R., Lough, A., McAlees, A., McCrindle R., 2011. Preparation and X-ray structural characterization of further stereoisomers of 1,2,5,6,9,10-hexabromocyclododecane. Chemosphere 84, 900-907.
Konstantinov, A., Chittim, B., Potter, D., Klein, J., Riddell, N., McCrindle, R., 2011. Is BDE-175 an important enough component of commercial octabromodiphenyl ether mixtures to be listed in Annex A of the Stockholm Convention? Chemosphere 82, 778-781.
Gemmill, B., Pleskach, K., Peters, L., Palace, V., Wautier, K., Park, B., Darling, C., Rosenberg, B., McCrindle, R., Tomy, G.T. 2011. Toxicokinetics of tetrabromoethylcyclohexane (TBECH) in juvenile brown trout (Salmo trutta) and effects on plasma sex hormones. Aquatic Toxicology 101, 309-317.
Chen, D., Letcher, R.J., Gauthier, L.T., Chu, S., McCrindle, R., Potter, D. 2011. Novel Methoxylated Polybrominated Diphenoxybenzene Congeners and Possible Sources in Herring Gull Eggs from the Laurentian Great Lakes of North America. Environmental Science & Technology 45, 9523-9530.
2010
Mundy, L.J., Jones, S.P., Crump, D., Herve, J.C., Konstantinov, A., Utley, F., Potter, D., Kennedy, S.W. 2010. Highly purified hexachlorobenzene induces cytochrome P4501A in primary cultures of chicken embryo hepatocytes. Toxicol Appl Pharmacol 248, 185-193.
Sverko, E., Reiner, E.J., Tomy, G.T., McCrindle, R., Shen, L., Arsenault, G., Zaruk, D., MacPherson, K.A., Marvin, C.H., Helm, P.A., McCarry, B.E. 2010. Compounds Structurally Related to Dechlorane Plus in Sediment and Biota from Lake Ontario (Canada). Environmental Science & Technology 44, 574-579.
Zhou, S.N., Reiner, E.J., Marvin, C., Helm, P., Riddell, N., Dorman, F., Misselwitz, M., Shen, L., Crozier, P., MacPherson, K., Brindle, I.D., 2010, Development of liquid chromatography atmospheric pressure chemical ionization tandem mass spectrometry for analysis of halogenated flame retardants in wastewater. Analytical and Bioanalytical Chemistry 396, 1311-1320.
Zhou, S.N., Reiner, E.J., Marvin, C., Kolic, T., Riddell, N., Helm, P., Dorman, F., Misselwitz, M., Brindle, I.D., 2010. Liquid chromatography-atmospheric pressure photoionization tandem mass spectrometry for analysis of 36 halogenated flame retardants in fish. Journal of Chromatography A 1217, 633-641.
Kopec, A.K., Burgoon, L.D., Ibrahim-Aibo, D., Mets, B.D., Tashiro, C., Potter, D., Sharratt, B., Harkema, J.R., Zacharewski, T.R. 2010. PCB153-elicited hepatic responses in the immature, ovariectomized C57BL/6 mice: Comparative toxicogenomic effects of dioxin and non-dioxin-like ligands. Toxicology and Applied Pharmacology 243, 359-371.
Kopec, A.K., Burgoon, L.D., Ibrahim-Aibo, D., Burg, A.R., Lee, A.W., Tashiro, C., Potter, D., Sharratt, B., Harkema, J.R., Rowlands, J.C., Budinsky, R.A., Zacharewski, T.R. 2010. Automated Dose-Response Analysis and Comparative Toxicogenomic Evaluation of the Hepatic Effects Elicited by TCDD, TCDF, and PCB126 in C57B/6 Mice. Toxicological Sciences 118, 286-297.
2009
Benskin, J.P., De Silva, A.O., Martin, L.J., Arsenault, G., McCrindle, R., Riddell, N., Mabury, S.A., Martin, J.W., 2009. Disposition of Perfluorinated Acid Isomers in Sprague-Dawley Rats; Part 1: Single Dose. Environmental Toxicology and Chemistry 28, 542-554.
De Silva, A.O., Benskin, J.P., Martin, L.J., Arsenault, G., McCrindle, R., Riddell, N., Martin, J.W., Mabury, S.A., 2009. Disposition of Perfluorinated Acid Isomers in Sprague-Dawley Rats; Part 2: Subchronic Dose. Environmental Toxicology and Chemistry 28, 555-567.
Frank, R.A., Fischer, K., Kavanagh, R., Burnison, B.K., Arsenault, G., Headley, J.V., Peru, K.M., Van der Kraak, G., Solomon, K.R., 2009. Effect of Carboxylic Acid Content on the Acute Toxicity of Oil Sands Naphthenic Acids. Environmental Science & Technology 43, 266-271.
Gauthier, L.T., Potter, D., Hebert, C.E., Letcher, R.J. 2009. Temporal Trends and Spatial Distribution of Non-polybrominated Diphenyl Ether Flame Retardants in the Eggs of Colonial Populations of Great Lakes Herring Gulls. Environmental Science & Technology 43, 312-317.
Khalaf, H., Larsson, A., Berg, H., McCrindle, R., Arsenault, G., Olsson, P.-E., 2009. Diastereomers of the Brominated Flame Retardant 1,2-Dibromo-4-(1,2 dibromoethyl)cyclohexane Induce Androgen Receptor Activation in the HepG2 Hepatocellular Carcinoma Cell Line and the LNCaP Prostate Cancer Cell Line. Environmental Health Perspectives 117, 1853-1859.
Kolic, T.M., Shen, L., MacPherson, K., Fayez, L., Gobran, T., Heim, P.A., Marvin, C.H., Arsenault, G., Reiner, E.J., 2009. The Analysis of Halogenated Flame Retardants by GC-HRMS in Environmental Samples. Journal of Chromatographic Science 47, 83-91.
Riddell, N., Arsenault, G., Benskin, J.P., Chittim, B., Martin, J.W., McAlees, A., McCrindle, R., 2009. Branched Perfluorooctane Sulfonate Isomer Qantification and Characterization in Blood Serum Samples by HPLC/ESI-MS(/MS). Environmental Science & Technology 43, 7902-7908.
Riddell, N., Arsenault, G., Klein, J., Lough, A., Marvin, C.H., McAlees, A., McCrindle, R., MacInnis, G., Sverko, E., Tittlemier, S., Tomy, G.T., 2009. Structural characterization and thermal stabilities of the isomers of the brominated flame retardant 1,2,5,6-tetrabromocyclooctane (TBCO). Chemosphere 74, 1538-1543.
Wang, Y., Arsenault, G., Riddell, N., McCrindle, R., McAlees, A., Martin, J.W., 2009. Perfluorooctane Sulfonate (PFOS) Precursors Can Be Metabolized Enantioselectively: Principle for a New PFOS Source Tracking Tool. Environmental Science & Technology 43, 8283-8289.
2008
Arsenault, G., Chittim, B., Gu, J., McAlees, A., McCrindle, R., Robertson, V., 2008. Separation and fluorine nuclear magnetic resonance spectroscopic (F-19 NMR) analysis of individual branched isomers present in technical perfluorooctanesulfonic acid (PFOS). Chemosphere 73, S53-S59.
Arsenault, G., Chittim, B., McAlees, A., McCrindle, R., Riddell, N., Yeo, B., 2008. Some issues relating to the use of perfluoro octane sulfonate (PFOS) samples as reference standards. Chemosphere 70, 616-625.
Arsenault, G., Lough, A., Marvin, C., McAlees, A., McCrindle, R., MacInnis, G., Pleskach, K., Potter, D., Riddell, N., Sverko, E., Tittlemier, S., Tomy, G., 2008. Structure characterization and thermal stabilities of the isomers of the brominated flame retardant 1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane. Chemosphere 72, 1163-1170.
Chadalapaka, G., Jutooru, I., McAlees, A., Stefanac, T., Safe, S., 2008. Structure-dependent inhibition of bladder and pancreatic cancer cell growth by 2-substituted glycyrrhetinic and ursolic acid derivatives. Bioorganic & Medicinal Chemistry Letters 18, 2633-2639.
Frank, R.A., Kavanagh, R., Burnison, B.K., Arsenault, G., Headley, J.V., Peru, K.M., Van Der Kraak, G., Solomon, K.R., 2008. Toxicity assessment of collected fractions from an extracted naphthenic acid mixture. Chemosphere 72, 1309-1314.
Kiyosawa, N., Kwekel, J.C., Burgoon, L.D., Dere, E., Williams, K.J., Tashiro, C., Chittim, B., Zacharewski, T.R., 2008. Species-specific regulation of PXR/CAR/ER-target genes in the mouse and rat liver elicited by o, p '-DDT. Bmc Genomics 9.
Kiyosawa, N., Kwekel, J.C., Burgoon, L.D., Williams, K.J., Tashiro, C., Chittim, B., Zacharewski, T.R., 2008. o,p'-DDT elicits PXR/CAR-, not ER-, mediated responses in the immature ovariectomized rat liver. Toxicological Sciences 101, 350-363.
Kiyosawa, N., Kwekel, J.C., Burgoon, L.D., Williams, K.J., Tashiro, C., Chittim, B., Zacharewski, T.R., 2008. o,p '-DDT elicits PXR/CAR-, not ER-, mediated responses in the immature ovariectomized rat liver (vol 101, pg 350, 2008). Toxicological Sciences 105, 231-231.
Konstantinov, A., Arsenault, G., Chittim, B., McAlees, A., McCrindle, R., Potter, D., Tashiro, C., Yeo, B., 2008. Identification of the minor components of Great Lakes DE-71 (TM) technical mix by means of H-1 NMR and GC/MS. Chemosphere 73, S39-S43.
Konstantinov, A., Bejan, D., Bunce, N.J., Chittim, B., McCrindle, R., Potter, D., Tashiro, C., 2008. Electrolytic debromination of PBDEs in DE-83 (TM) technical decabromodiphenyl ether. Chemosphere 72, 1159-1162.
Konstantinov, A., McCrindle, R., Arsenault, G., Lough, A.J., 2008. 4,5,6,7-tetrabromo-1,1,3-trimethyl-3(2,3,4,5-tetrabromophenyl) indane. Acta Crystallographica Section E-Structure Reports Online 64, O439-U2297.
Kopec, A.K., Boverhof, D.R., Burgoon, L.D., Ibrahim-Aibo, D., Harkema, J.R., Tashiro, C., Chittim, B., Zacharewski, T.R., 2008. Comparative toxicogenomic examination of the hepatic effects of PCB126 and TCDD in immature, ovariectomized C57BL/6 mice. Toxicological Sciences 102, 61-75.
Riddell, N., Arsenault, G., Lough, A., McAlees, A., McCrindle, R., Meissner, J., Robertson, V., 2008. The three-dimensional structural characterization of hexachlorocyclopentenyl-dibromocyclooctane (HCDBCO). Chemosphere 73, 479-483.
Riddell, N., McCrindle, R., Arsenault, G., Lough, A.J., 2008. (1R,2R,5R,6R,9S,10S,13S,14S)-1,6,7,8,9,14,15,16,17,17-decachloropentacyc lo[12.2.1.1(6,9).0(2,13).0(5,10)]octadeca-7,15-diene. Acta Crystallographica Section E-Structure Reports Online 64, O1249-U1767.
Riddell, N., McCrindle, R., Arsenault, G., Lough, A.J., 2008. (1R,2R,5R,6S,9R,10S,13S,14S,18R)-1,6,7,8,9,14,15,16,17,17,18-undecachlor opentacyclo[12.2.1.1(6,9).0(2,13).0(5,10)]octadeca-7,15-diene. Acta Crystallographica Section E-Structure Reports Online 64, O1250-U1776.
Stapleton, H.M., Allen, J.G., Kelly, S.M., Konstantinov, A., Klosterhaus, S., Watkins, D., McClean, M.D., Webster, T.F., 2008. Alternate and new brominated flame retardants detected in US house dust. Environmental Science & Technology 42, 6910-6916.
Tomy, G.T., Pleskach, K., Arsenault, G., Potter, D., McCrindle, R., Marvin, C.H., Sverko, E., Tittlemier, S., 2008. Identification of the novel cycloaliphatic brominated flame retardant 1,2-dihromo-4-(1,2-dibromoethyl)cyclo-hexane in Canadian arctic beluga (Delphinapterus leucas). Environmental Science & Technology 42, 543-549.
Tomy, G.T., Thomas, C.R., Zidane, T.M., Murison, K.E., Pleskach, K., Hare, J., Arsenault, G., Marvin, C.H., Sverko, E., 2008. Examination of isomer specific bioaccumulation parameters and potential in vivo hepatic metabolites of syn- and anti-Dechlorane Plus isomers in juvenile rainbow trout (Oncorhynchus mykiss). Environmental Science & Technology 42, 5562-5567.
Alaee, M., Parrott, J., Arsenault, G., Reiner, E.J. 2008. Advances in Organohalogen Compound Research; selected papers from the 25th international symposium on halogenated environmental organic pollutants and POPs. Chemosphere 73, S1-S1.
2007
Arsenault, G., Chittim, B., McAlees, A., McCrindle, R., 2007. Nuclear magnetic resonance spectral characterization and semi-empirical calculations of conformations of alpha- and gamma-1,2,5,6,9,10-hexabromocyclododecane. Chemosphere 67, 1684-1694.
Arsenault, G., Chittim, B., McAlees, A., McCrindle, R., Potter, D., Tashiro, C., Yeo, B., 2007. Mass spectral studies of native and mass-labeled perfluorooctanesulfonamides. Rapid Communications in Mass Spectrometry 21, 929-936.
Arsenault, G., Konstantinov, A., Marvin, C.H., MacInnis, G., McAlees, A., McCrindle, R., Riddell, N., Tomy, G.T., Yeo, B., 2007. Synthesis of the two minor isomers, delta- and epsilon-1,2,5,6,9,10-hexabromocyclododecane, present in commercial hexabromocyclododecane. Chemosphere 68, 887-892.
Arsenault, G., McAlees, A., McCrindle, R., Riddell, N., 2007. Analysis of perfluoroalkyl anion fragmentation pathways for perfluoroalkyl carboxylates and sulfonates during liquid chromatography/tandem mass spectrometry: evidence for fluorine migration prior to secondary and tertiary fragmentation. Rapid Communications in Mass Spectrometry 21, 3803-3814.
Chintharlapalli, S., Papineni, S., Jutooru, I., McAlees, A., Safe, S., 2007. Structure-dependent activity of glycyrrhetinic acid derivatives as peroxisorne proliferator-activated receptor gamma agonists in colon cancer cells. Molecular Cancer Therapeutics 6, 1588-1598.
Liu, P., Goddard, J.D., Arsenault, G., Gu, J., McAlees, A., McCrindle, R., Robertson, V., 2007. Theoretical studies of the conformations and F-19 NMR spectra of linear and a branched perfluorooctanesulfonamide (PFOSAmide). Chemosphere 69, 1213-1220.
Marvin, C.H., MacInnis, G., Alaee, M., Arsenault, G., Tomy, G.T., 2007. Factors influencing enantiomeric fractions of hexabromocyclododecane measured using liquid chromatography/tandem mass spectrometry. Rapid Communications in Mass Spectrometry 21, 1925-1930.